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The purpose of this research was to produce multi-dimensional scaffolds containing biocompatible particles and fibres. To achieve this, two techniques were combined and used: T-Junction microfluidics and electrohydrodynamic (EHD) processing. The former was used to form layers of monodispersed bovine serum albumin (BSA) bubbles, which upon drying formed porous scaffolds. By altering the T-Junction processing parameters, bubbles with different diameters were produced and hence the scaffold porosity could be controlled. EHD processing was used to spray or spin poly(lactic-co-glycolic) (PLGA), polymethysilsesquioxane (PMSQ) and collagen particles/fibres onto the scaffolds during their production and after drying. As a result, multifunctional BSA scaffolds with controlled porosity containing PLGA, PMSQ and collagen particles/fibres were obtained. Product morphology was studied by optical and scanning electron microscopy. These products have potential applications in many advanced biomedical, pharmaceutical and cosmetic fields e.g. bone regeneration, drug delivery, cosmetic cream lathers, facial scrubbing creams etc.

Original publication

DOI

10.1088/1758-5082/6/4/045010

Type

Journal article

Journal

Biofabrication

Publication Date

12/2014

Volume

6

Addresses

Department of Mechanical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.

Keywords

Animals, Cattle, Lactic Acid, Organosilicon Compounds, Polymers, Collagen, Polyglycolic Acid, Serum Albumin, Bovine, Biocompatible Materials, Microfluidic Analytical Techniques, Materials Testing, Microbubbles, Porosity, Tissue Scaffolds, Nanofibers