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Despite an increasing knowledge about the causes of cancer, this disease is difficult to cure and still causes far too high a death rate. Based on advances in our understanding of disease pathogenesis, novel treatment concepts, including targeting the tumor microenvironment, have been developed and are being combined with established treatment regimens such as surgical removal and radiotherapy. Yet it is obvious that we need additional strategies to prevent tumor relapse and metastasis. Given its exceptional high expression in most cancers with low abundance in normal tissues, tenascin-C appears an ideal candidate for tumor treatment. Here, we will summarize the current applications of targeting tenascin-C as a treatment for different tumors, and highlight the potential of this therapeutic approach.

Original publication

DOI

10.1080/19336918.2014.1000074

Type

Journal article

Journal

Cell adhesion & migration

Publication Date

01/2015

Volume

9

Pages

141 - 153

Addresses

a Inserm U1109, MN3T; Université de Strasbourg; Strasbourg, France; LabEx Medalis; Université de Strasbourg; Strasbourg, France. Fédération de Médecine Translationnelle de Strasbourg (FMTS) ; Strasbourg , France.

Keywords

Extracellular Matrix, Animals, Humans, Neoplasms, Tenascin, Immunotherapy, RNA Interference, Tumor Microenvironment