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Heterogeneity in the supramolecular organization of immunological synapses arises from the involvement of different cells, distinct environmental stimuli, and varying levels of protein expression. There may also be heterogeneity in the types and amounts of cell surface proteins and lipids that transfer between lymphocytes during immune surveillance. In addition, immune cells can be involved in the assembly of a 'viral synapse', such that micrometer-scale organization of proteins at intercellular contacts occurs during transmission of a virus between T cells. Thus, while there may be unity in molecular mechanisms underlying the organization of cell surface receptors at immune cell synapses, there is diversity in their function.

Original publication

DOI

10.1016/j.smim.2003.09.005

Type

Journal article

Journal

Seminars in immunology

Publication Date

12/2003

Volume

15

Pages

317 - 324

Addresses

Department of Biological Sciences, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. d.davis@imperial.ac.uk

Keywords

T-Lymphocytes, Intercellular Junctions, Animals, Humans, Viruses, Receptors, Immunologic, Lymphocyte Activation, Cell Communication, Signal Transduction, Immunologic Surveillance, Models, Immunological