Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Weakness is reported in Parkinson's but always unadjusted for recognized factors that influence muscle strength such as participants' age, gender, and body size. This may obscure the true association of Parkinson's with muscle strength.To evaluate the relationship between grip strength, Parkinson's severity, and duration adjusting for these factors.Age, gender, height, weight, grip strength, Unified Parkinson's Disease Rating Score (UPDRS) motor score, Hoehn and Yahr (H&Y) stage, disease duration, number of comorbidities and medications, Barthel score, Mini Mental State Examination (MMSE) score, and Malnutrition Universal Screening Tool (MUST) score were recorded.Fifty-seven of 79 (72%) people with Parkinson's resident in one town were recruited. Age, gender, height, and Parkinson's severity were the most significant determinants of grip strength. Each unit increase in UPDRS motor score and H&Y stage was associated with lower grip strength in univariate linear regression analyses adjusted for gender: -0.3 kg strength (95% confidence interval = -0.51, -0.09), P = .006 for each additional UPDRS point, and -3.87 kg strength (95% confidence interval = -6.54, -1.21), P = .005 for each additional H&Y stage. Disease duration was not associated with grip strength. In multivariate regression, Parkinson's severity remained strongly associated with grip strength (UPDRS score P = .09; H&Y stage P = .04).This is the first demonstration that increasing severity of Parkinson's was associated with weaker grip after adjustment for known influences on muscle strength. Participants' age, gender, and body size also had a significant impact on strength. Adjustment of reported values for all these factors is essential to allow accurate reporting of grip strength values in intervention trials and comparison between different groups.

Type

Journal article

Journal

Neurorehabilitation and neural repair

Publication Date

10/2015

Volume

29

Pages

889 - 896

Addresses

University of Southampton, Southampton, UK University Hospital Southampton NHS Foundation Trust, Southampton, UK hcr@soton.ac.uk.

Keywords

Humans, Muscle Weakness, Parkinson Disease, Hand Strength, Severity of Illness Index, Cross-Sectional Studies, Time Factors, Aged, Aged, 80 and over, Middle Aged, Female, Male