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Tremendous advances have occurred in our understanding of the pathogenesis of hand osteoarthritis (OA) and these are beginning to be applied to trials targeted at modification of the disease course. The purpose of this expert opinion, consensus driven exercise is to provide detail on how one might use and apply hand imaging assessments in disease modifying clinical trials. It includes information on acquisition methods/techniques (including guidance on positioning for radiography, sequence/protocol recommendations/hardware for MRI); commonly encountered problems (including positioning, hardware and coil failures, sequences artifacts); quality assurance/control procedures; measurement methods; measurement performance (reliability, responsiveness, validity); recommendations for trials; and research recommendations.

Original publication

DOI

10.1016/j.joca.2015.03.003

Type

Journal article

Journal

Osteoarthritis and cartilage

Publication Date

05/2015

Volume

23

Pages

732 - 746

Addresses

Institute of Bone and Joint Research, Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, NSW, Australia. Electronic address: David.Hunter@sydney.edu.au.

Keywords

Cartilage, Articular, Humans, Osteoarthritis, Disease Progression, Magnetic Resonance Imaging, Hand Joints, Clinical Trials as Topic, Practice Guidelines as Topic