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This article reviews the development of the immune response through neonatal, infant and adult life, including pregnancy, ending with the decline in old age. A picture emerges of a child born with an immature, innate and adaptive immune system, which matures and acquires memory as he or she grows. It then goes into decline in old age. These changes are considered alongside the risks of different types of infection, autoimmune disease and malignancy.

Original publication

DOI

10.1098/rspb.2014.3085

Type

Journal article

Journal

Proceedings of the Royal Society B: Biological Sciences

Publication Date

12/2015

Volume

282

Addresses

Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.

Keywords

Immune System, Humans, Communicable Diseases, Neoplasms, Autoimmune Diseases, Aging, Pregnancy, Female, Immunity, Innate, Adaptive Immunity, Biological Evolution