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A new formulation of volatile nanodroplets stabilized by a protein and polymer coating and loaded with magnetic nanoparticles is developed. The droplets show enhanced stability and phase conversion efficiency upon ultrasound exposure compared with existing formulations. Magnetic targeting, encapsulation, and release of an anticancer drug are demonstrated in vitro with a 40% improvement in cytotoxicity compared with free drug.

Original publication




Journal article


Adv mater

Publication Date





5484 - 5492


breast cancer, chemotherapy, microbubbles, nanodroplets, ultrasound, Antineoplastic Agents, Antineoplastic Agents, Phytogenic, Cell Survival, Drug Carriers, Drug Delivery Systems, Drug Liberation, Equipment Design, Ferric Compounds, Fluorocarbons, Humans, MCF-7 Cells, Magnetite Nanoparticles, Oleic Acid, Paclitaxel, Polyethylene Glycols, Quaternary Ammonium Compounds, Serum Albumin, Ultrasonography