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An occupational analysis of 56 men with scleroderma in the United Kingdom showed no evidence that silica exposure was implicated in the onset of the disease, in contrast with older published reports suggesting that such exposure explained an important proportion of the occurrence of the disease in men. Of the major occupational exposures suggested from case reports, only organic solvents were reported to any extent in this series. No significant increase in exposure to organic solvents was noted, however, in a case control analysis.

Original publication

DOI

10.1136/ard.51.12.1322

Type

Journal article

Journal

Annals of the rheumatic diseases

Publication Date

12/1992

Volume

51

Pages

1322 - 1324

Addresses

Arthritis and Rheumatism Council, Epidemiology Research Unit, University of Manchester, United Kingdom.

Keywords

Humans, Scleroderma, Systemic, Occupational Diseases, Silicon Dioxide, Formaldehyde, Epoxy Compounds, Solvents, Case-Control Studies, Retrospective Studies, Cross-Sectional Studies, Occupational Exposure, Middle Aged, Male