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This article has reviewed available data on the environmental agents, including occupational factors, that might influence susceptibility to scleroderma. None of the exposures considered could act independently in causing the disease and individually would only be responsible for a small proportion of cases. Nonetheless, they do provide useful insight into the possible mechanisms of disease causation.


Journal article


Rheum dis clin north am

Publication Date





737 - 749


Breast Implants, Drug-Related Side Effects and Adverse Reactions, Dust, Environmental Exposure, Humans, Occupational Exposure, Risk Factors, Scleroderma, Systemic, Silicon Dioxide, Silicone Elastomers, Solvents