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This article has reviewed available data on the environmental agents, including occupational factors, that might influence susceptibility to scleroderma. None of the exposures considered could act independently in causing the disease and individually would only be responsible for a small proportion of cases. Nonetheless, they do provide useful insight into the possible mechanisms of disease causation.

Original publication

DOI

10.1016/s0889-857x(05)70298-2

Type

Journal article

Journal

Rheumatic diseases clinics of North America

Publication Date

11/1996

Volume

22

Pages

737 - 749

Addresses

ARC Epidemiology Research Unit, University of Manchester, United Kingdom.

Keywords

Humans, Scleroderma, Systemic, Silicon Dioxide, Silicone Elastomers, Dust, Solvents, Risk Factors, Breast Implants, Environmental Exposure, Occupational Exposure, Drug-Related Side Effects and Adverse Reactions