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OBJECTIVES: To determine the effect of HLA type and hypocomplementaemia on the duration and severity of joint involvement in parvovirus infection (HPV). METHODS: Forty seven patients were selected on a geographical basis from 83 with proven HPV infection during an outbreak that occurred in Oxfordshire in 1993. They were contacted by questionnaire a year later. Thirty five patients were available for examination and blood sampling. Subjects were typed for HLA-DRB1 alleles and HLA-B27 status. Immunological profiles, including C3 and C4 complement components, were determined. RESULTS: Joint symptoms occurred in all patients. They resolved within a week in 12 patients and persisted beyond one year in 19. On review, none had a picture of rheumatoid arthritis, but three patients had developed carpal tunnel syndrome. Decreased C4 was found in four. The HLA frequencies were similar to those in controls; however, joint symptoms persisted for more than one week in all HLA-DR4 positive patients (p = 0.009). There was no relation between the severity of joint symptoms and either HLA type, or hypocomplementaemia. CONCLUSIONS: Joint symptoms are common in parvovirus infection and the presence of HLA-DR4 may be associated with persistence of joint symptoms beyond one week. This study revealed no evidence of progression to rheumatoid arthritis.

Original publication

DOI

10.1136/ard.55.1.63

Type

Journal article

Journal

Annals of the rheumatic diseases

Publication Date

01/1996

Volume

55

Pages

63 - 65

Addresses

Rheumatology Department, Nuffield Orthopaedic Centre, Oxford, United Kingdom.

Keywords

Humans, Arthritis, Infectious, Erythema Infectiosum, HLA-B27 Antigen, HLA-DR Antigens, HLA Antigens, Follow-Up Studies, Disease Outbreaks, Adult, Middle Aged, England, Complement System Proteins, Complement C3, Complement C4, Female, Male