Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

To validate a new method to identify responders (relative effect per patient (REPP) >0.2) using the OMERACT-OARSI criteria as gold standard in a large multicentre sample.The REPP ([score before - after treatment]/score before treatment) was calculated for 845 patients of a large multicenter European cohort study for THR. The patients with a REPP >0.2 were defined as responders. The responder rate was compared to the gold standard (OMERACT-OARSI criteria) using receiver operator characteristic (ROC) curve analysis for sensitivity, specificity and percentage of appropriately classified patients.With the criterion REPP>0.2 85.4% of the patients were classified as responders, applying the OARSI-OMERACT criteria 85.7%. The new method had 98.8% sensitivity, 94.2% specificity and 98.1% of the patients were correctly classified compared to the gold standard.The external validation showed a high sensitivity and also specificity of a new criterion to identify a responder compared to the gold standard method. It is simple and has no uncertainties due to a single classification criterion.

Original publication

DOI

10.1016/j.joca.2015.10.012

Type

Journal article

Journal

Osteoarthritis and cartilage

Publication Date

03/2016

Volume

24

Pages

480 - 483

Addresses

Department of Orthopaedics, Stadtspital Triemli, Birmendsdorferstr. 497, CH-8063 Zurich, Switzerland. Electronic address: joerg.huber2@triemli.zuerich.ch.

Keywords

Humans, Osteoarthritis, Hip, Pain Measurement, Treatment Outcome, Arthroplasty, Replacement, Hip, Severity of Illness Index, Sensitivity and Specificity, Cohort Studies, Reproducibility of Results, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male