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Although specific pathogenic entities contributing to diabetic risk, such as central adiposity, ectopic fat accumulation, hyperlipidaemia and inflammation, are well-characterized, the response of cellular systems to such insults are less well understood. This short review highlights the effect of increasing fat mass on ectopic fat accumulation, the role of triacylglycerols (triglycerides) in Type 2 diabetes mellitus and cardiovascular disease pathogenesis, and selected current therapeutic strategies used to ameliorate these risk factors.

Original publication

DOI

10.1042/cs20080050

Type

Journal article

Journal

Clinical science (London, England : 1979)

Publication Date

01/2009

Volume

116

Pages

113 - 123

Addresses

Clinical Sciences Research Institute, Warwick Medical School, University Hospitals Coventry and Warwickshire, Coventry CV2 2DX, UK. margaret.hill@warwick.ac.uk

Keywords

Muscle, Skeletal, Liver, Adipocytes, Myocytes, Cardiac, Humans, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Obesity, Thiazolidinediones, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Adiposity, Lipid Metabolism