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Although specific pathogenic entities contributing to diabetic risk, such as central adiposity, ectopic fat accumulation, hyperlipidaemia and inflammation, are well-characterized, the response of cellular systems to such insults are less well understood. This short review highlights the effect of increasing fat mass on ectopic fat accumulation, the role of triacylglycerols (triglycerides) in Type 2 diabetes mellitus and cardiovascular disease pathogenesis, and selected current therapeutic strategies used to ameliorate these risk factors.

Original publication




Journal article


Clin sci (lond)

Publication Date





113 - 123


Adipocytes, Adiposity, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Lipid Metabolism, Liver, Muscle, Skeletal, Myocytes, Cardiac, Obesity, Thiazolidinediones