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This paper provides an analysis of microfluidic techniques for the production of nanoscale lipid-based vesicular systems. In particular we focus on the key issues associated with the microfluidic production of liposomes. These include, but are not limited to, the role of lipid formulation, lipid concentration, residual amount of solvent, production method (including microchannel architecture), and drug loading in determining liposome characteristics. Furthermore, we propose microfluidic architectures for the mass production of liposomes with a view to potential industrial translation of this technology.

Original publication

DOI

10.1038/srep25876

Type

Journal article

Journal

Scientific reports

Publication Date

19/05/2016

Volume

6

Addresses

Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research Building, University of Oxford, Oxford, United Kingdom.

Keywords

Liposomes, Solvents, Drug Delivery Systems, Microfluidics, Particle Size