Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Mechanical forces play increasingly recognized roles in T cell receptor (TCR) signal transduction. Hu and Butte (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201511053) demonstrate that actin is required for T cells to generate forces at the TCR and that exogenous application of force can emulate these cytoskeletal forces and trigger T cell activation.

Original publication

DOI

10.1083/jcb.201605072

Type

Journal article

Journal

The Journal of cell biology

Publication Date

06/2016

Volume

213

Pages

501 - 503

Addresses

Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskelatal Sciences, The University of Oxford, Oxford OX3 7FY, England, UK Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016 michael.dustin@kennedy.ox.ac.uk.

Keywords

T-Lymphocytes, Animals, Humans, Receptors, Antigen, T-Cell, Microscopy, Atomic Force, Lymphocyte Activation, Signal Transduction, Models, Biological