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Phosphatidylinositol 5-phosphate (PtdIns5P) is emerging as a potential lipid messenger involved in several cell types, from plants to mammals. Expression of IpgD, a PtdIns(4,5)P(2) 4-phosphatase induces Src kinase and Akt, but not ERK activation and enhances interleukin II promoter activity in T-cells. Expression of a new PtdIns5P interacting domain blocks IpgD-induced T-cell activation and selective signaling molecules downstream of TCR triggering. Altogether, these data suggest that PtdIns5P may play a sensor function in setting the threshold of T-cell activation and contributing to maintain T-cell homeostasis.

Original publication

DOI

10.1016/j.febslet.2010.04.051

Type

Journal article

Journal

FEBS letters

Publication Date

06/2010

Volume

584

Pages

2455 - 2460

Addresses

Institut National de la Santé et de la Recherche Médicale, Unité 891, Centre de Recherche en Cancérologie de Marseille, Marseille, France.

Keywords

T-Lymphocytes, Humans, Plants, Phosphoric Monoester Hydrolases, src-Family Kinases, Phosphatidylinositol Phosphates, Receptors, Antigen, T-Cell, Interleukin-2, Lymphocyte Activation, Signal Transduction, Proto-Oncogene Proteins c-akt