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We assessed the efficacy of intraoperative frozen-section histology in detecting infection in failed arthroplasties in 106 hips and knees. We found inflammatory changes consistent with infection (an average of one or more neutrophil polymorphs or plasma cells per high-power field in several samples) in 18 cases; there was a significant growth on bacterial culture in 20 cases. Compared with the bacterial cultures, the frozen sections provided two false-negative results and three false-positive results (sensitivity, 90%; specificity, 96%; and accuracy, 95%). The positive predictive value was 88%, the negative value, 98%. These results support the inclusion of intra-operative frozen-section histology in any protocol for revision arthroplasty for loose components.

Type

Journal article

Journal

The Journal of bone and joint surgery. British volume

Publication Date

01/1995

Volume

77

Pages

28 - 33

Addresses

Nuffield Orthopaedic Centre, Oxford, England, UK.

Keywords

Humans, Prosthesis-Related Infections, Recurrence, Inflammation, Prosthesis Failure, Reoperation, Frozen Sections, Sensitivity and Specificity, Predictive Value of Tests, Hip Prosthesis, Knee Prosthesis, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male