Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

In this study, we show that in the absence of a protective NK cell response, murine CMV causes destruction of splenic white and red pulp pulp areas in the first few days of infection. Destruction of T zone stroma is associated with almost complete loss of dendritic cells and T cells. We provide evidence that the virus replicates in red and white pulp stroma in vivo and in vitro. Control of white pulp viral replication is associated with migration of murine CMV-specific activated NK cells to white pulp areas, where they associate directly with podoplanin-expressing T zone stromal cells. Our data explain how NK cells protect the lymphoid-rich white pulp areas from CMV, allowing protective adaptive T cell-dependent immune responses to develop, and how this mechanism might break down in immunocompromised patients.

Original publication

DOI

10.4049/jimmunol.180.10.6768

Type

Journal article

Journal

J immunol

Publication Date

15/05/2008

Volume

180

Pages

6768 - 6776

Keywords

Animals, Antigens, Ly, Chemokine CXCL10, Chemokine CXCL11, Chemotaxis, Leukocyte, Flow Cytometry, Herpesviridae Infections, Immunohistochemistry, Killer Cells, Natural, Lasers, Lectins, C-Type, Mice, Microdissection, Microscopy, Confocal, Muromegalovirus, NK Cell Lectin-Like Receptor Subfamily A, Receptors, CXCR3, Receptors, NK Cell Lectin-Like, Reverse Transcriptase Polymerase Chain Reaction, Spleen, T-Lymphocytes