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Fibroblasts are important sentinel cells in the immune system and, here, it is proposed that these cells play a critical role in the switch from acute inflammation to adaptive immunity and tissue repair. It is suggested that chronic inflammation occurs because of disordered fibroblast behaviour in which failure to switch off their inflammatory programme leads to the inappropriate survival and retention of leukocytes within inflamed tissue.

Type

Journal article

Journal

Trends immunol

Publication Date

04/2001

Volume

22

Pages

199 - 204

Keywords

Acute-Phase Reaction, Animals, Fibroblasts, Humans, Inflammation, Leukocytes, Signal Transduction