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Immune cell development and function occur in specialized immunological tissues, the function of which requires active cell migration and interactions between hematopoietic cells and underlying networks of stromal cells. These cells provide a scaffold on which immune cell migrate, provide microenvironments for efficient antigen presentation, and provide signals required for immune cell recruitment and survival. Technical advances in imaging technologies including multiphoton microscopy and 3D tissue reconstructions are being combined with computational approaches to provide new insights into the process of cell migration and function in immunological tissues.

Original publication

DOI

10.1007/978-1-4939-6931-9_1

Type

Chapter

Publication Date

01/2017

Volume

1591

Pages

1 - 8

Addresses

Department of Biology, Centre for Immunology and Infection, University of York, York, North Yorkshire, YO10 5DD, UK. mark.coles@york.ac.uk.

Keywords

Animals, Humans, Microscopy, Tissue Engineering, Hematopoiesis, Cell Movement, Antigen Presentation, Homeostasis, Tissue Scaffolds