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The coding polymorphism (rs1130866) within the surfactant protein B gene is known to associate with certain respiratory abnormalities. We investigated, using spirometry and fluorescence-based PCR, whether this variant influenced pulmonary function in healthy, nonsmoking men. We found no association of pulmonary function with genotype at the rs1130866 locus.

Original publication

DOI

10.2170/physiolsci.SC002607

Type

Journal article

Journal

J physiol sci

Publication Date

06/2007

Volume

57

Pages

199 - 202

Keywords

Adult, Cohort Studies, Exons, Forced Expiratory Volume, Gene Frequency, Genetic Predisposition to Disease, Humans, Male, Polymorphism, Single Nucleotide, Pulmonary Surfactant-Associated Protein B, Pulmonary Surfactants, Pulmonary Ventilation, Vital Capacity