Germline variation at 8q24 and prostate cancer risk in men of European ancestry.
Matejcic M., Saunders EJ., Dadaev T., Brook MN., Wang K., Sheng X., Olama AAA., Schumacher FR., Ingles SA., Govindasami K., Benlloch S., Berndt SI., Albanes D., Koutros S., Muir K., Stevens VL., Gapstur SM., Tangen CM., Batra J., Clements J., Gronberg H., Pashayan N., Schleutker J., Wolk A., West C., Mucci L., Kraft P., Cancel-Tassin G., Sorensen KD., Maehle L., Grindedal EM., Strom SS., Neal DE., Hamdy FC., Donovan JL., Travis RC., Hamilton RJ., Rosenstein B., Lu Y-J., Giles GG., Kibel AS., Vega A., Bensen JT., Kogevinas M., Penney KL., Park JY., Stanford JL., Cybulski C., Nordestgaard BG., Brenner H., Maier C., Kim J., Teixeira MR., Neuhausen SL., De Ruyck K., Razack A., Newcomb LF., Lessel D., Kaneva R., Usmani N., Claessens F., Townsend PA., Gago-Dominguez M., Roobol MJ., Menegaux F., Khaw K-T., Cannon-Albright LA., Pandha H., Thibodeau SN., Schaid DJ., PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium None., Wiklund F., Chanock SJ., Easton DF., Eeles RA., Kote-Jarai Z., Conti DV., Haiman CA.
Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p