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Recent studies have identified interleukin 10 as a differentiation factor for a novel subset of immune suppressive regulatory T cells. Here, Hervé Groux and Fiona Powrie discuss the role that these cells play in the regulation of immune responses to enteric antigens and suggest that a deficiency in these cells might be involved in the pathogenesis of inflammatory bowel disease.

Original publication

DOI

10.1016/s0167-5699(99)01510-8

Type

Journal article

Journal

Immunology today

Publication Date

10/1999

Volume

20

Pages

442 - 445

Addresses

INSERM U343, Hôpital de l'Archet, Route de Saint Antoine de Ginestières, 06200 Nice, France. groux@unice.fr

Keywords

T-Lymphocyte Subsets, Animals, Humans, Mice, Inflammatory Bowel Diseases, Interleukin-10, Cell Differentiation