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Publications

The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma

Ozyerli-Goknar E. et al, (2019), Cell death & disease

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function.

Fagan V. et al, (2019), J med chem, 62, 9008 - 9025

AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells.

Nikolaou N. et al, (2019), J steroid biochem mol biol, 189, 218 - 227

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming.

Ebrahimi A. et al, (2019), Nat chem biol, 15, 519 - 528

A Chemical Probe For Tudor Domain Protein Spindlin1 to Investigate Chromatin Functions

Fagan V. et al, (2019)

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.

Vazquez-Rodriguez S. et al, (2019), Angew chem int ed engl, 58, 515 - 519

Functional Characterization of a GGPPS Variant Identified in Atypical Femoral Fracture Patients and Delineation of the Role of GGPPS in Bone-Relevant Cell Types.

Roca-Ayats N. et al, (2018), J bone miner res, 33, 2091 - 2098

A GGPS1 mutation found by WES in three sisters with bisphosphonate-associated atypical femoral fractures

Roca-Ayats N. et al, (2018), European journal of human genetics, 26, 679 - 679

Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.

Yang S-M. et al, (2018), J med chem, 61, 4883 - 4903

Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition.

Belle R. et al, (2017), Chem commun (camb), 53, 13264 - 13267

Functional Effects of the p.Asp188Tyr Mutation in the Geranylgeranyl Diphosphate Synthase (GGPS1) Gene Associated with Bisphosphonate-related Atypical Femoral Fractures.

Roca-Ayats N. et al, (2017), Journal of bone and mineral research, 32, S321 - S322

The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate).

Lawson MA. et al, (2017), J bone miner res, 32, 1860 - 1869

GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates.

Roca-Ayats N. et al, (2017), N engl j med, 376, 1794 - 1795

Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine.

Sun S. et al, (2016), Bioconjug chem, 27, 329 - 340

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.

Tsoumpra MK. et al, (2015), Bone, 81, 478 - 486

Synthesis and characterization of novel phosphonocarboxylate inhibitors of RGGT.

Coxon FP. et al, (2014), Eur j med chem, 84, 77 - 89

Biochemical properties of human dehydrogenase/reductase (SDR family) member 7.

Stambergova H. et al, (2014), Chem biol interact, 207, 52 - 57

An epigenetic screen identifies bromodomain-containing protein 4 (BRD4) as a critical component for osteoblast differentiation

Kramm A. et al, (2013), International journal of experimental pathology, 94, A18 - A18

The Successful Design Of A Novel Highly Potent Nitrogen-Containing Bisphosphonate With Lower Bone Affinity.

Ebetino FH. et al, (2013), Journal of bone and mineral research, 28

Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.

Rose NR. et al, (2012), J med chem, 55, 6639 - 6643

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