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Publications

KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas

Heward JA. et al, (2020)

GGPS1 Mutations Cause Muscular Dystrophy/Hearing Loss/Ovarian Insufficiency Syndrome.

Foley AR. et al, (2020), Ann neurol

The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma.

Ozyerli-Goknar E. et al, (2019), Cell death dis, 10

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function.

Fagan V. et al, (2019), J med chem, 62, 9008 - 9025

A Chemical Probe For Tudor Domain Protein Spindlin1 to Investigate Chromatin Functions

Fagan V. et al, (2019)

AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells.

Nikolaou N. et al, (2019), J steroid biochem mol biol, 189, 218 - 227

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming.

Ebrahimi A. et al, (2019), Nat chem biol, 15, 519 - 528

A Chemical Probe For Tudor Domain Protein Spindlin1 to Investigate Chromatin Functions

Fagan V. et al, (2019)

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.

Vazquez-Rodriguez S. et al, (2019), Angew chem int ed engl, 58, 515 - 519

Functional Characterization of a GGPPS Variant Identified in Atypical Femoral Fracture Patients and Delineation of the Role of GGPPS in Bone-Relevant Cell Types.

Roca-Ayats N. et al, (2018), J bone miner res, 33, 2091 - 2098

A GGPS1 mutation found by WES in three sisters with bisphosphonate-associated atypical femoral fractures

Roca-Ayats N. et al, (2018), European journal of human genetics, 26, 679 - 679

Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.

Yang S-M. et al, (2018), J med chem, 61, 4883 - 4903

Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition.

Belle R. et al, (2017), Chem commun (camb), 53, 13264 - 13267

Functional Effects of the p.Asp188Tyr Mutation in the Geranylgeranyl Diphosphate Synthase (GGPS1) Gene Associated with Bisphosphonate-related Atypical Femoral Fractures.

Roca-Ayats N. et al, (2017), Journal of bone and mineral research, 32, S321 - S322

The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate).

Lawson MA. et al, (2017), J bone miner res, 32, 1860 - 1869

GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates.

Roca-Ayats N. et al, (2017), N engl j med, 376, 1794 - 1795

Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine.

Sun S. et al, (2016), Bioconjug chem, 27, 329 - 340

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.

Tsoumpra MK. et al, (2015), Bone, 81, 478 - 486

Synthesis and characterization of novel phosphonocarboxylate inhibitors of RGGT.

Coxon FP. et al, (2014), Eur j med chem, 84, 77 - 89

Biochemical properties of human dehydrogenase/reductase (SDR family) member 7.

Stambergova H. et al, (2014), Chem biol interact, 207, 52 - 57

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