Clarke Group | Translational Immunometabolism
There is a growing understanding that the metabolic state and energy source of an immune cell can profoundly affect its behaviour and the outcome of the immune response. However, how immune cell metabolism varies in human autoimmune disease is largely unknown. Our research focuses on the role of immune cell metabolism in the often-severe autoimmune disease systemic lupus erythematosus (SLE). Understanding this is important, because it has the potential to lead to new therapeutic strategies.
We are also interested in how immune cell metabolism varies in space and time, and at the single cell level. Our work combines advanced mass spectrometry and mass spectrometry imaging techniques with established immunological tools and models to understand this. Again, we seek to explore how this varies in autoimmune disease, and to determine the underlying mechanisms responsible.