Research groups
Annika Jödicke
Dr. sc. ETH
Senior Researcher in Pharmacoepidemiology
Pharmacoepidemiology | Real-World Evidence
My work as a pharmacoepidemiologist is to improve healthcare for patients by using de-identified healthcare data to generate robust and reliable real-world evidence on the utilisation, safety and effectiveness of medicines.
I am a pharmacist by training, and joined the Health Data Sciences Group in 2020 after completing my doctoral training at ETH Zurich, Switzerland.
Several of my projects use data from across Europe, mapped to the OMOP common data model. I have a particular research interest and expertise in geriatric pharmacoepidemiology, vaccine effectiveness research and regulatory pharmacoepidemiology.
My areas of work include conducting causal inference and drug utilisation studies for the national and European regulators (e.g. in the context of DARWIN EU) as well as methodological work to minimize confounding bias in observational studies.
Since May 2025, I am honoured to co-lead with Prof. Prieto-Alhambra the academic side of the Innovative Health Initiative’s GREG project to generate, pilot-test, and disseminate evidence-based guidance for the use of real-world evidence to support regulatory and HTA decision-making.
Recent publications
Secular Trends in the Use of Valproate-Containing Medicines in Women of Childbearing Age in Europe: A Multinational DARWIN EU Network Study.
Journal article
Bellas L. et al, (2025), Pharmacoepidemiol Drug Saf, 34
Clusters of post-acute COVID-19 symptoms: a latent class analysis across 9 databases and 7 countries.
Journal article
López-Güell K. et al, (2025), J Clin Epidemiol, 185
Trends in prescription opioid use in Europe: A DARWIN EU® multinational cohort study including seven European countries.
Journal article
Xie J. et al, (2025), Front Pharmacol, 16
Development of the ECHOES national dataset: a resource for monitoring post-acute and long-term COVID-19 health outcomes in England.
Journal article
Allen H. et al, (2025), Front Public Health, 13
Standardised and Reproducible Phenotyping Using Distributed Analytics and Tools in the Data Analysis and Real World Interrogation Network (DARWIN EU).
Journal article
Dernie F. et al, (2024), Pharmacoepidemiol Drug Saf, 33
Incidence of post-acute COVID-19 symptoms across healthcare settings in seven countries: an international retrospective cohort study using routinely-collected data.
Journal article
Xie J. et al, (2024), EClinicalMedicine, 77
Time Series Methods to Assess the Impact of Regulatory Action: A Study of UK Primary Care and Hospital Data on the Use of Fluoroquinolones.
Journal article
Guo Y. et al, (2024), Pharmacoepidemiol Drug Saf, 33
Incident Use of Hydroxychloroquine for the Treatment of Rheumatoid Arthritis and Systemic Lupus Erythematosus During the COVID-19 Pandemic.
Journal article
Mercadé-Besora N. et al, (2024), Arthritis Care Res (Hoboken), 76, 1173 - 1178
Calculating daily dose in the Observational Medical Outcomes Partnership Common Data Model.
Journal article
Burkard T. et al, (2024), Pharmacoepidemiol Drug Saf, 33
Relationship between HLA genetic variations, COVID-19 vaccine antibody response, and risk of breakthrough outcomes.
Journal article
Xie J. et al, (2024), Nat Commun, 15
Effectiveness of COVID-19 vaccines to prevent long COVID: data from Norway.
Journal article
Trinh NT. et al, (2024), Lancet Respir Med, 12, e33 - e34
The role of COVID-19 vaccines in preventing post-COVID-19 thromboembolic and cardiovascular complications.
Journal article
Mercadé-Besora N. et al, (2024), Heart, 110, 635 - 643
The effectiveness of COVID-19 vaccines to prevent long COVID symptoms: staggered cohort study of data from the UK, Spain, and Estonia.
Journal article
Català M. et al, (2024), Lancet Respir Med, 12, 225 - 236
Observational methods for COVID-19 vaccine effectiveness research: an empirical evaluation and target trial emulation.
Journal article
Català M. et al, (2024), Int J Epidemiol, 53
Machine learning methods for propensity and disease risk score estimation in high-dimensional data: a plasmode simulation and real-world data cohort analysis.
Journal article
Guo Y. et al, (2024), Front Pharmacol, 15
Collateral effects of the COVID-19 pandemic on endocrine treatments for breast and prostate cancer in the UK: a cohort study.
Journal article
Barclay NL. et al, (2024), Ther Adv Med Oncol, 16
The impact of the UK COVID-19 lockdown on the screening, diagnostics and incidence of breast, colorectal, lung and prostate cancer in the UK: a population-based cohort study.
Journal article
Barclay NL. et al, (2024), Front Oncol, 14
Supporting Pharmacovigilance Signal Validation and Prioritization with Analyses of Routinely Collected Health Data: Lessons Learned from an EHDEN Network Study.
Journal article
Gauffin O. et al, (2023), Drug Saf, 46, 1335 - 1352
"The burden of post-acute COVID-19 symptoms in a multinational network cohort analysis".
Journal article
Kostka K. et al, (2023), Nat Commun, 14
Collateral effects of the COVID-19 pandemic on endocrine treatments for breast and prostate cancer in the UK: implications for bone health
Preprint
Barclay NL. et al, (2023)
Drug utilization analysis of osteoporosis medications in seven European electronic health databases.
Journal article
Tan EH. et al, (2023), Osteoporos Int, 34, 1771 - 1781
Risk of adverse events following the initiation of antihypertensives in older people with complex health needs: a self-controlled case series in the United Kingdom.
Journal article
Jödicke AM. et al, (2023), Age Ageing, 52
HLA alleles, COVID-19 vaccine antibody response and real-world breakthrough outcomes
Preprint
Xie J. et al, (2023)
The role of COVID-19 vaccines in preventing post COVID-19 thromboembolic and cardiovascular complications: a multinational cohort study
Preprint
Mercadé-Besora N. et al, (2023)
The Effectiveness of COVID-19 Vaccines to Prevent Long COVID Symptoms: Staggered Cohort Analyses of Data from the UK, Spain, and Estonia
Preprint
Catala Sabate M. et al, (2023)
Characterising complex health needs and the use of preventive therapies in the older population: a population-based cohort analysis of UK primary care and hospital linked data.
Journal article
Elhussein L. et al, (2023), BMC Geriatr, 23
Characterising the treatment of thromboembolic events after COVID-19 vaccination in 4 European countries and the US: An international network cohort study.
Journal article
Markus AF. et al, (2023), Front Pharmacol, 14
Observational methods for COVID-19 vaccine effectiveness research: a trial emulation and empirical evaluation
Preprint
Català M. et al, (2022)
Oral Bisphosphonates Are Associated With Increased Risk of Severe Acute Kidney Injury in Elderly Patients With Complex Health Needs: A Self-Controlled Case Series in the United Kingdom.
Journal article
Oda T. et al, (2022), J Bone Miner Res, 37, 1270 - 1278
Treatment patterns for osteoporosis medications in five European countries: a multinational real world cohort analysis
Conference paper
Robinson D. et al, (2022), Osteoporosis International, 32
The impact of COVID-19 on population-level drug utilization of alendronate
Conference paper
Tan EH. et al, (2022), Osteoporosis International, 32, 314 - 315
Validation of Algorithms to Identify Acute Myocardial Infarction, Stroke, and Cardiovascular Death in German Health Insurance Data.
Journal article
Platzbecker K. et al, (2022), Clin Epidemiol, 14, 1351 - 1361
The risk of severe acute kidney injury with use of anti-hypertensives in the elderly: A self-controlled case series analysis
Conference paper
Tan EHC. et al, (2022), PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 31, 633 - 634
Bisphosphonate use and risk of severe acute kidney injury: a self-controlled case series in frail elderly patients in the UK
Conference paper
Oda T. et al, (2021), Pharmacoepidemiology and Drug Safety, 30, 19 - 19
Fracture risk following the initiation of antihypertensive therapy amongst frail elderly people: a self-controlled case series analysis
Conference paper
Jodicke A. et al, (2021), Pharmacoepidemiology and Drug Safety, 30, 232 - 232
bstracts of the 37th International Conference on Pharmacoepidemiology & Therapeutic Risk Management, Virtual, August 23, 2021.
Conference paper
(2021), Pharmacoepidemiol Drug Saf, 30 Suppl 1, 3 - 439
Use of and adherence to bisphosphonates in elderly patients with complex health needs: an analysis of UK primary care records
Conference paper
ELHUSSEIN L. et al, (2021)