Research groups
Websites
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Ancestrally Inclusive Musculoskeletal Single-cell (AIMS) Network
Creating a global atlas of the musculoskeletal system
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Snelling Group
Soft Tissue Repair
- Human Cell Atlas project
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Chan Zuckerberg Initiative
An Ancestrally Inclusive Atlas of Healthy Musculoskeletal Tissues
Carla Cohen
Computational Biologist
- Analysis of single-cell RNA-seq data from musculoskeletal tissues
- Trainer in computational biology
Delivering an ethnically diverse cell atlas of human musculoskeletal tissue
I am a computational biologist working in David Sims' Computational Biology group at the WIMM and in Sarah Snelling’s Soft Tissue Repair group at the Botnar Research Centre.
I work on the Human Cell Atlas project, a global consortium which aims to map all cells in the healthy human body. I analyse single-nuclear RNA-seq data from musculoskeletal tissues including tendon, muscle, bone and capsule to create an ethnically diverse atlas of healthy cells in the adult joint. This work will produce an open-source comprehensive resource for researchers around the world and will provide a foundation for further studies on human disease.
I am also a trainer in computational methods including Linux, R programming and core/advanced methods in single-cell RNA-seq analysis using R and Python, in collaboration with the African Institute of Biomedical Science and Technology in Harare, Zimbabwe.
My work is funded from the Chan-Zuckerberg Initiative and fits within their ambitious goal to solve human disease by 2100.
I completed my DPhil in the Dunn School of Pathology with William James, and went on to a postdoctoral position with Dixie Mager in the Terry Fox Laboratory, Vancouver, Canada. From 2011-2022 I worked in the University of Oxford with Paul Wordsworth and Julian Knight on the genetics and epigenetics of ankylosing spondylitis, an inflammatory arthritis. I took a career break from 2013-2017 when I had young children, and received funding from the University’s Returning Carer’s Fund when I returned to work. I am a keen supporter of public engagement with science, and improving equality, diversity and inclusion in science.
Key publications
Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis.
Journal article
Brown AC. et al, (2023), Cell Genom, 3
Disruption of c-MYC Binding and Chromosomal Looping Involving Genetic Variants Associated With Ankylosing Spondylitis Upstream of the RUNX3 Promoter.
Journal article
Cohen CJ. et al, (2021), Front Genet, 12
An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation.
Journal article
Roberts AR. et al, (2016), Ann Rheum Dis, 75, 2150 - 2156
The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression.
Journal article
Vecellio M. et al, (2016), Ann Rheum Dis, 75, 1534 - 1540
Human Th1 and Th17 cells exhibit epigenetic stability at signature cytokine and transcription factor loci.
Journal article
Cohen CJ. et al, (2011), J Immunol, 187, 5615 - 5626
Placenta-specific expression of the interleukin-2 (IL-2) receptor β subunit from an endogenous retroviral promoter.
Journal article
Cohen CJ. et al, (2011), J Biol Chem, 286, 35543 - 35552
Recent publications
Fibroblast specialisation across microanatomy in a single-cell atlas of healthy human Achilles tendon
Preprint
Cohen CJ. et al, (2025)
Exploring cellular changes in ruptured human quadriceps tendons at single-cell resolution.
Journal article
Mimpen JY. et al, (2025), J Physiol, 603, 4535 - 4554
Exploring cellular changes in ruptured human quadriceps tendons at single-cell resolution
Preprint
Mimpen J. et al, (2024)
Single nucleus and spatial transcriptomic profiling of healthy human hamstring tendon.
Journal article
Mimpen JY. et al, (2024), FASEB J, 38
Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis.
Journal article
Brown AC. et al, (2023), Cell Genom, 3
Chromosome conformation capture approaches to investigate 3D genome architecture in Ankylosing Spondylitis.
Journal article
Davidson C. et al, (2023), Front Genet, 14
FUNCTIONAL GENOMICS INVESTIGATION OF THE ANKYLOSING SPONDYLITIS ASSOCIATED LOCUS RUNX3
Conference paper
Cohen C. et al, (2022), ANNALS OF THE RHEUMATIC DISEASES, 81, 231 - 231
Functional Genomic Analysis of a RUNX3 Polymorphism Associated With Ankylosing Spondylitis.
Journal article
Vecellio M. et al, (2021), Arthritis Rheumatol, 73, 980 - 990