Senior Postdoctoral Researcher
I obtained a first class honors degree from the The Open University in 2008. Following that I joined the Nuffield Department of Surgery at Oxford where I graduated with a DPhil in 2013. My thesis focused on investigating the role of co-regulators of p53 in prostate development and prostate cancer progression. My current research in Claire Edwards’s lab focuses on the fatal hematologic malignancy multiple myeloma.
I am currently investigating the tumour-suppressive effects of adiponectin, an adipokine which has previously been shown to kill myeloma cells. I am also interested in the pro-survival mechanisms of myeloma cells, in particular the process of autophagy. Many patients experience resistance to conventional singular therapies, and so using combination therapies to target pathways such as adiponectin signalling and the autophagy pathway could enhance myeloma cell death and therefore patient outcome.
Myeloma cells down-regulate adiponectin in bone marrow adipocytes via TNF-alpha
MORRIS E. et al, (2019), Journal of bone and mineral research
Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease.
Gooding S. et al, (2019), Nat commun, 10