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- Dustin, M Group | Immunological synapse Research Group
Enas Abu Shah
Postdoctoral Research Assistant
Quantitative analysis of human regulatory networks.
I obtained my PhD in Nanotechnology from the Technion Institute of Technology (Israel). During my PhD in Dr. Kinneret Keren's lab, I established an in-vitro cell-like system to study the biophysical aspect of cytoskeletal organisation and in particular the process of symmetry breaking in acto-myosin networks .
I joined the lab of Prof. Michael Dustin as a joint postdoctoral fellow with Omer Dushek to study immunoregulatory networks using mathematical models. I have established a three-dimensional collagen gel incorporating human effector T-cells and antigen presenting cells (APCs) to mimic 3D tissue architecture. Using time-lapse microscopy I follow the interactions between the T-cells and the APCs in the presence and absence of regulatory T-cells. By analysing the kinetic parameters of the contacts formed between the T-cells and APCs and fitting them to a variety of mathematical models we anticipate to reveal the inhibition mechanism employed by regulatory T-cells as a function of antigen dose and potency. These models will include communication via direct cell-cell contacts, soluble factors and extracellular vesicles.
My work is supported in part by the Human Frontiers Science Program [2,3].
- Abu-Shah, E. and K. Keren, Symmetry breaking in reconstituted actin cortices, ed. M. Balasubramanian. Vol. 3. 2014.
- HFSP AWARDS 2015, Research Grants
- International research project gets high level of funding
HFSP AWARDS 2015
Abu Shah E. et al, (2015), Methods in cell biology, 128, 287 - 301
Ofer N. et al, (2014), Cytoskeleton (Hoboken, N.J.), 71, 341 - 350
Artzy-Schnirman A. et al, (2014), Journal of peptide science : an official publication of the European Peptide Society, 20, 446 - 450
Abu Shah E. and Keren K., (2014), eLife, 3
Abu Shah E. and Keren K., (2013), Current opinion in cell biology, 25, 550 - 557