Contact information
https://orcid.org/0000-0002-6111-7355
Centre for Human Genetics, University of Oxford.
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Holm Uhlig
Professor of Paediatric Gastroenterology
- Director Centre for Human Genetics
The gastrointestinal immune system has evolved to counteract the invasion of pathogens. To allow a strong inflammatory immune response during infection but avoid tissue damage there is a need for effective immune regulation. Defects in immune regulation lead to immunopathology such as inflammatory bowel disease or environmental enteropathy or celiac disease.
About one-fifth of all patients with inflammatory bowel disease present with initial symptoms during childhood and adolescents. In particular in the very young children patients, an underlying immunodeficiency may cause Iinflammatory bowel disease-like symptoms. The analysis of immune deviation in children with inflammatory bowel disease does contribute to the understanding of the complex puzzle of molecular mechanisms involved in IBD.
Recent publications
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Upadacitinib for Induction of Remission in Pediatric Ulcerative Colitis: An International Multi‑center Study.
Yerushalmy-Feler A. et al, (2024), J crohns colitis
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A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease.
Thomas T. et al, (2024), Nat immunol, 25, 2152 - 2165
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The circulating methylome in childhood-onset inflammatory bowel disease.
Noble A. et al, (2024), J crohns colitis
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Biallelic PI4KA Mutations Disrupt B-Cell Metabolism and Cause B-Cell Lymphopenia and Hypogammaglobulinemia.
Saettini F. et al, (2024), J clin immunol, 45
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Successful Allogeneic Hematopoietic Cell Transplantation for Patients with IL10RA Deficiency in Japan.
Tomomasa D. et al, (2024), J clin immunol, 45