Contact information
Hopin Lee
PhD
NHMRC Postdoctoral Research Fellow
Hopin is a postdoctoral researcher funded by the Australian National Health and Medical Research Council. His research focuses on understanding how health and medical interventions work, or why they do not. This involves studying the mechanistic pathways by which health interventions cause change in clinical and policy outcomes. Hopin’s work generates knowledge from clinical trials and observational studies that inform the adaptation of interventions and optimises their implementation into clinical practice and policy.
Hopin also conducts research on research conduct, with a particular focus on transparency and reproducibility. His work aims to identify current practices (eg. journal policies) that limit research transparency and reproducibility, then finding ways of changing such practices. Hopin leads a collaborative project funded by the Berkeley Initiative for Transparency in the Social Sciences to develop a reporting guideline for mechanistic evaluations of clinical studies in health and medicine. He also collaborates on a methodological audit of non-randomised comparative-effectiveness studies funded by UK NIHR Biomedical Research Centres.
Hopin’s clinical interests are in the management of chronic pain and musculoskeletal conditions (primarily back pain, knee osteoarthritis and rheumatoid arthritis), and in the prevention of chronic diseases. His PhD focused on the causal mechanisms of low back pain and was awarded by the University of New South Wales in June 2017. Hopin joined CSM and RRIO in December 2017.
Key publications
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Mechanisms of implementing public health interventions: a pooled causal mediation analysis of randomised trials.
Journal article
Lee H. et al, (2018), Implement sci, 13
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Causal mechanisms in the clinical course and treatment of back pain.
Journal article
Lee H. et al, (2016), Best pract res clin rheumatol, 30, 1074 - 1083
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How does pain lead to disability? A systematic review and meta-analysis of mediation studies in people with back and neck pain.
Journal article
Lee H. et al, (2015), Pain, 156, 988 - 997
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Effect of Intensive Patient Education vs Placebo Patient Education on Outcomes in Patients With Acute Low Back Pain: A Randomized Clinical Trial.
Journal article
Traeger AC. et al, (2018), Jama neurol
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Mediation Analysis.
Journal article
Lee H. et al, (2019), Jama, 321, 697 - 698
Recent publications
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Reduced organ damage accumulation in adult patients with SLE on anifrolumab plus standard of care compared to real-world external controls
Journal article
Touma Z. et al, (2025), Annals of the rheumatic diseases
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Application of the target trial emulation framework to external comparator studies
Journal article
Arnold K. et al, (2024), Frontiers in drug safety and regulation, 4
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Reporting of Observational Studies Explicitly Aiming to Emulate Randomized Trials: A Systematic Review.
Journal article
Hansford HJ. et al, (2023), Jama netw open, 6
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Understanding how health interventions or exposures produce their effects using mediation analysis.
Journal article
Cashin AG. et al, (2023), Bmj, 382
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Do health education initiatives assist socioeconomically disadvantaged populations? A systematic review and meta-analyses.
Journal article
Karran EL. et al, (2023), Bmc public health, 23