Huw Colin-York
Senior Postdoctoral Research Fellow in Synthetic Biology
Huw Colin-York is a EPSRC Postdoctoral Fellow in Synthetic Biology, working at the Kennedy Institute of Rheumatology at the University of Oxford in the lab of Prof Marco Fritzsche. His research focuses on understanding basic T-cell immunology through the development of novel mechanobiological tools. He has worked extensively on advancing the method of Traction Force Microscopy (TFM) by integrating it with super-resolution fluorescence microscopy, pioneering its application to immune cell mechanobiology. More recently, harnessing synthetic biology approaches, he has developed synthetic antigen-presenting cells (APCs) based on soft hydrogel microspheres to probe T-cell force generation and enhance T-cell expansion for immunotherapy.
Recent publications
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Publisher Correction: Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells.
Journal article
Barnkob MB. et al, (2024), Nat commun, 15
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Semmaphorin 3 A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells.
Journal article
Barnkob MB. et al, (2024), Nat commun, 15
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Quantifying Immune Cell Force Generation Using Traction Force Microscopy.
Journal article
Issler M. et al, (2023), Methods mol biol, 2654, 363 - 373
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Extended mechanical force measurements using structured illumination microscopy.
Journal article
Korobchevskaya K. et al, (2021), Philos trans a math phys eng sci, 379
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Astigmatic traction force microscopy (aTFM).
Journal article
Li D. et al, (2021), Nat commun, 12