I am currently pursuing a DPhil in Molecular and Cellular Medicine in the Professor Claudia Monaco’s team and our team investigates the innate immune response through pattern recognition receptors in the pathogenesis of atherosclerosis.
Dendritic cell immunoreceptor (DCIR) is a C-type lectin receptor that is mainly expressed in the myeloid lineage. DCIR transduces inhibitory signals in the immune response during infection and chronic inflammation. Aberrant expression of DCIR contributes to the aetiology of several autoimmune diseases, indicating that DCIR plays an important role in the homeostasis of the immune system. My DPhil project aims to better understand how DCIR in myeloid cells orchestrates inflammation in atherosclerosis.