James K-K Chan
MA(Cantab), DPhil(Oxon), FRCS(Plast)
Honorary Departmental Clinical Lecturer
- Consultant & Research Lead in Plastic Reconstructive Surgery (Stoke Mandeville & Wycombe General Hospitals, National Spinal Injuries Centre, Buckinghamshire Healthcare NHS Trust)
Wound healing
My mission is to bring about the translation of lab research to improve outcomes in patients who require reconstructive surgery. My main area of research interest is wound healing in different tissue types while my clinical interests lie in the functional reconstruction of the musculoskeletal system, including in people with spinal cord injury.
I graduated from the University of Cambridge in 2004 and completed my Higher Surgical Training in Plastic Surgery in the Oxford Deanery in 2019. In 2017, I undertook a one-year Cochrane Fellowship during which I was involved in the critical appraisal of systematic reviews and dissemination of evidence-based practice. Subsequently, in 2018, I undertook an intensive one-year subspecialist fellowship training in Reconstructive Microsurgery at the Chang Gung Memorial Hospital in Taiwan, the largest microsurgery unit worldwide.
Between 2010 and 2014, I took time out of my clinical training to embark upon full time translational research at the Kennedy Institute of Rheumatology, Oxford University. Under the mentorship of Prof Jagdeep Nanchahal, Prof Nikki Horwood and Prof Sir Marc Feldmann, I identified the innate immune response as a therapeutic target and delineated the early inflammatory pathway in fracture repair, successfully defending my DPhil thesis in 2014. During this period, I was awarded the Wellcome Clinical Research Training Fellowship, Royal College of Surgeons of England Research Fellowship and Senior Scholarship of Lincoln College, University of Oxford. I have also received grants from the Paton-Masser Memorial Fund (BAPRAS) and the Royal College of Surgeons of Edinburgh. In 2016, I was awarded the Starter Grant for Clinical Lecturers by the Academy of Medical Sciences.
Key publications
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Soft-tissue reconstruction of open fractures of the lower limb: muscle versus fasciocutaneous flaps.
Journal article
Chan JK-K. et al, (2012), Plast reconstr surg, 130, 284e - 295e
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Lower limb reconstruction
Chapter
Chan JK. et al, (2015), Plastic and reconstructive surgery, 607 - 627
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Dictionary of Science
Book
Clugston MJ. et al, (2014)
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Alarmins: awaiting a clinical response.
Journal article
Chan JK. et al, (2012), J clin invest, 122, 2711 - 2719
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Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to GAlert.
Journal article
Lee G. et al, (2018), Proc natl acad sci u s a, 115, E4463 - E4472
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Low-dose TNF augments fracture healing in normal and osteoporotic bone by up-regulating the innate immune response.
Journal article
Chan JK. et al, (2015), Embo mol med, 7, 547 - 561
Recent publications
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Flap reconstruction of pressure ulcers in patients with spinal cord injury: a retrospective cohort study.
Journal article
Mishra A. et al, (2025), Spinal cord
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Outcomes of Flap Reconstruction for Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis of Clinical Studies.
Journal article
Reed AJM. et al, (2024), Plast reconstr surg, 154, 1118 - 1130
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Functional and Immunologic Mapping of Domains of the Reticulocyte-Binding Protein Plasmodium vivax PvRBP2a.
Journal article
Tay MZ. et al, (2024), J infect dis, 230, e737 - e742
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International Lower Limb Collaborative Paediatric subpopulation analysis (INTELLECT-P) study: multicentre, international, retrospective audit of paediatric open fractures.
Journal article
Allan AY. et al, (2024), Bjs open, 8
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What is new in the 5th edition of the World Health Organization classification of mature B and T/NK cell tumors and stromal neoplasms?
Journal article
Attygalle AD. et al, (2024), J hematop, 17, 71 - 89