Jinsen Lu
MD.PhD
Postdoctoral Research Associate in Single Cell Assay Development
Anti-ageing therapy and bone cancer multiomics
Background and research
He is a qualified orthopaedic surgeon in china graduating from an 8 years bachelor-master integral surgical programme at AHMU in China. He complete my surgical resident training in 1st affiliated hospital of the university of science and technology in china with a focus on traumatic orthopaedics. He joined the group of musculoskeletal ageing and oncology led by prof. James Edwards and Claire Edwards in 2020 to study the extraskeletal effects of bisphosphonates. Then from 2024, he join the group of Udo Oppermann as a postdoctoral research associate to develop spatial single cell multiomics platform for research of multiple myeloma.
Current research focus on the following area:
1. Constructing multi-level (WGS/RNA/protein) platform with novel spatial single cell technique to study the pathology of multiple myeloma in various clinical settings.
2. Exploring the Anti-ageing potential and subcellular mechanism of novel bisphosphonates via systemic screening, multi-omics assessment, AI-based prediction and multi-level validation.
2. Development and evaluation of stem cell derived exosome loaded 3D bioprinting bone tissue engineering scaffold for diabetic bone lesion.
3. Exploring the novel mechanism of rare bone disease via single cell and spatial transcriptome sequencing.
4. Clinical trials and epidemiological analysis of orthopedic surgery.
Core competence
1. Experience of orthopedic surgery including ORIF of common limb fracture, TKA/THA and robot assisted pelvic CRIF and spine surgery.
2. Cell biology, molecular biology, microscopy and animal experiments.
3. RNAseq, scRNAseq, WGS, CETSA-MS, Proteomics/scProteomics, Xenium.
Collaboration
Welcome any collaboration from bone tissue engineering, WGBS, epigenetic ageing, advanced in vivo imaging, organoid culture and clinical trials.
Key publications
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Extracellular vesicles from endothelial progenitor cells prevent steroid-induced osteoporosis by suppressing the ferroptotic pathway in mouse osteoblasts based on bioinformatics evidence
Lu J. et al, (2019), Scientific reports, 9
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Detection of Mitochondria Membrane Potential to Study CLIC4 Knockdown-induced HN4 Cell Apoptosis In Vitro
Lu J. et al, (2018), Journal of visualized experiments
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Interferon-stimulated gene factor 3 complex is required for the induction of sterile α motif and HD domain-containing protein 1 expression by interferon-α in SMMC-7721 cells
ZHU M. et al, (2015), Molecular medicine reports, 12, 7176 - 7180
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Lack of association of tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms (rs3850641 and rs17568) with coronary heart disease and stroke: A systematic review and meta-analysis
Wang B., (2018), The anatolian journal of cardiology
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Inhibition of Hepatitis B virus replication by SAMHD1
Chen Z. et al, (2014), Biochemical and biophysical research communications, 450, 1462 - 1468
Recent publications
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Association between socioeconomic status and survival in patients with hepatocellular carcinoma
Zheng Y. et al, (2021), Cancer medicine, 10, 7347 - 7359
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Robot-assisted vs freehand cannulated screw placement in femoral neck fractures surgery
Zheng Y. et al, (2021), Medicine, 100, e25926 - e25926
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TRPV4 Complexes With the Na+/Ca2+ Exchanger and IP3 Receptor 1 to Regulate Local Intracellular Calcium and Tracheal Tension in Mice
Zhang J. et al, (2019), Frontiers in physiology, 10
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Extracellular vesicles from endothelial progenitor cells prevent steroid-induced osteoporosis by suppressing the ferroptotic pathway in mouse osteoblasts based on bioinformatics evidence
Lu J. et al, (2019), Scientific reports, 9
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Resveratrol reduces store-operated Ca2+ entry and enhances the apoptosis of fibroblast-like synoviocytes in adjuvant arthritis rats model via targeting ORAI1–STIM1 complex
Lu J. et al, (2019), Biological research, 52
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Resveratrol alleviates inflammatory injury and enhances the apoptosis of fibroblast‑like synoviocytes via mitochondrial dysfunction and ER stress in rats with adjuvant arthritis
Lu J. et al, (2019), Molecular medicine reports
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Detection of Mitochondria Membrane Potential to Study CLIC4 Knockdown-induced HN4 Cell Apoptosis In Vitro
Lu J. et al, (2018), Journal of visualized experiments
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Reducing‐Autophagy Derived Mitochondrial Dysfunction during Resveratrol Promotes Fibroblast‐Like Synovial Cell Apoptosis
Cao W. et al, (2018), The anatomical record, 301, 1179 - 1188