Research groups
Lei Clifton
BSc, MSc, PhD
Honorary Departmental Senior Medical Statistician
Statistical expertise in epidemiology and clinical studies.
I joined the Nuffield Department of Population Health (NDPH) in 2019 as the team leader of the Translational Epidemiology Unit (TEU), under its Director Prof David Hunter. I lead a programme of research in translational cancer epidemiology. Key research includes assessing the performance of large-scale information on lifestyle and environment, assisting in development of exposure assessment instruments suitable for use at scale.
From 2014 - 2018, I worked in the Centre for Statistics in Medicine (CSM), where I lead statistical work on clinical trials, observational studies, and research on trial methodology. I was a senior advisor on the NIHR Research Design Service (RDS) team, which provides free advice on research design to researchers in the South Central region. I collaborated extensively with principle investigators in trial design and grant applications.
During my 5 years in CSM, I also provided statistical supervision in fellowship applications, taught statistics at the postgraduate level, and review grant proposals for the NIHR. I was a Scientific Research Committee (SRC) member of the Northern Ireland Chest Heart and Stroke (NICHS), responsible for reviewing proposals and allocating research grants.
From 2009 - 2014, I worked in the Institute of Biomedical Engineering, in the University of Oxford, where I undertook research into statistical time-series models for providing early warning of deterioration in post-surgery patients. From 2007-2009, I was a post-doctoral researcher in the Nuffield Department of Clinical Neurosciences, University of Oxford, where I developed mathematical models and prototype apparatus for measuring the lung function of ICU patients.
I was awarded a PhD in Statistical Signal Processing in 2007 from UMIST (now the University of Manchester), after completing my BSc and MSc degrees in Electrical Engineering at the Beijing Institute of Technology, China. I joined CSM in 2014.
Joining CSM and then NDPH has been one of the best choices I have made in my life, as I thoroughly enjoy working with the team on epidemiology and other medical studies. When I am at home, you can find me practising yoga, making noise on the violin, planting in the garden, or sewing pillowcases for my two boys.
Recent publications
When to and when not to use machine learning in risk prediction models.
Journal article
Clifton L. et al, (2026), Lancet Digit Health
Cardiac health assessment across scenarios and devices using a multimodal foundation model pretrained on data from 1.7 million individuals.
Journal article
Gu X. et al, (2026), Nat Mach Intell, 8, 220 - 233
ssociations between disease-specific polygenic risk scores and disease-specific causes of death in the UK Biobank cohort
Preprint
Liu W. et al, (2025)
Multimorbidity, disease clusters and risk of all-cause and cause-specific mortality: a population-based prospective cohort study.
Journal article
Littlejohns TJ. et al, (2025), Sci Rep, 15
DrAgent: empowering Large Language Models as medical agents for multi-hop medical reasoning
Conference paper
Liu F. et al, (2025), Findings of the Association for Computational Linguistics: EMNLP 2025, 15656 - 15668