Nasim Zargar
Honorary Departmental Product Development Scientist and Senior Production Manager
My work is focussed on the design and development of novel medical devices and the translation of these products from the research lab to the clinic. Since 2012 I have held a postdoctoral research position with professor Carr, working on the design and development of Biopatch and Bioyarn, two biomimetic implants developed for soft tissue repair. By stimulating the endogenous repair of tendons using biophysical cues this new generation of implants promises to improve the clinical outcome of tendon surgery. The preclinical evaluations of Bioyarn and Biopatch have now been concluded and both products are expected to enter the clinical trial phase in 2016. In addition to my research, I oversee the manufacturing of Biopatch and Bioyarn in accordance with GMP standards and I am responsible for obtaining the regulatory approval for clinical trials and CE marking.
Prior to working on the Biopatch and Bioyarn projects, I obtained my DPhil from the Department of Engineering Science at the University of Oxford. My thesis was focused on the role of mechanical loading and growth factor therapy in tendon regeneration.
Key publications
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Platelet-rich plasma protects tenocytes from adverse side effects of dexamethasone and ciprofloxacin.
Zargar Baboldashti N. et al, (2011), Am j sports med, 39, 1929 - 1935
Recent publications
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Effect of annealing on the mechanical properties and the degradation of electrospun polydioxanone filaments.
Abhari RE. et al, (2017), J mech behav biomed mater, 67, 127 - 134
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A layered electrospun and woven surgical scaffold to enhance endogenous tendon repair.
Hakimi O. et al, (2015), Acta biomater, 26, 124 - 135
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Fabrication of continuous electrospun filaments with potential for use as medical fibres.
Mouthuy P-A. et al, (2015), Biofabrication, 7
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Repairing damaged tendon and muscle: are mesenchymal stem cells and scaffolds the answer?
Davies BM. et al, (2013), Regen med, 8, 613 - 630
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A novel in vitro loading system for high frequency loading of cultured tendon fascicles (vol 35, pg 205, 2013)
Adekanmbi I. et al, (2013), Medical engineering & physics, 35, 1051 - 1051