Rafael Pinedo-Villanueva
BA, MSc, MSc, PhD
Associate Professor
- Senior Health Economist
- Head, Health Economics and Outcomes Research group
Understanding diseases and healthcare interventions to help inform decision-making in health
How do diseases affect people’s health and quality of life? What burden do interventions place on the healthcare system, patients , and their families? What decisions should healthcare systems make as they spend limited resources? With my work I try to answer these questions with regards to a wide variety of diseases, with a particular interest in musculoskeletal conditions. My work focuses primarily on osteoporosis and fracture prevention, osteoarthritis, and rare musculoskeletal diseases such as osteogenesis imperfecta and XLH.
I use routinely collected data (real-world evidence) to understand the journey that people with these diseases make as they receive care, what this costs the healthcare system, and how their quality of life is affected. I use all this information to build economic models that can then help us better understand what the most efficient ways of treating patients are likely to be.
I lead the Health Economics and Outcomes Research Group within the Centre for Statistics in Medicine in the Department. Our portfolio includes a wide range of projects on different therapeutic areas, interventions, data sources, and methods, as well as the health economic component of primarily clinical studies lasting anywhere from one to seven years. The National Institute for Health Research (NIHR), charity organisations both national and international, and industry partners are the main funders of our research. My work is highly collaborative as our research is undertaken working together with medics, statisticians, allied health professionals, and patients themselves.
I studied Economics and Political Science in the United States, completed an MSc in Public Policy in Venezuela, and then went on to do an MSc and PhD in Health Economics in the UK. Having studied in three so different countries, it is no surprise I am captivated by diversity, of any and all kinds but especially historical, political, cultural, ethnic, even gastronomical, and simply in terms of what matters to people as they go about and make decisions in their lives.
Key publications
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Expected Benefits and Budget Impact From a Microsimulation Model Support the Prioritization and Implementation of Fracture Liaison Services.
Journal article
Pinedo-Villanueva R. et al, (2023), J bone miner res, 38, 499 - 511
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Association between surgeon volume and patient outcomes after elective shoulder replacement surgery using data from the National Joint Registry and Hospital Episode Statistics for England: population based cohort study.
Journal article
Valsamis EM. et al, (2023), Bmj, 381
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Prevalence and Mortality of Individuals With X-Linked Hypophosphatemia: A United Kingdom Real-World Data Analysis.
Journal article
Hawley S. et al, (2020), J clin endocrinol metab, 105, e871 - e878
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Cost-effectiveness of unicompartmental compared with total knee replacement: a population-based study using data from the National Joint Registry for England and Wales.
Journal article
Burn E. et al, (2018), Bmj open, 8
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Health Care Costs Associated With Muscle Weakness: A UK Population-Based Estimate.
Journal article
Pinedo-Villanueva R. et al, (2019), Calcif tissue int, 104, 137 - 144
Recent publications
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Activity outcomes after hip arthroplasty: an information tool based on patients' experience captured in a hospital registry.
Journal article
Cole S. et al, (2025), Bmc musculoskelet disord, 26
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Double burdened yet resilient: quality of life of caregivers of people with X-linked hypophosphatemia.
Journal article
Pinedo-Villanueva R. et al, (2025), Jbmr plus, 9
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Health-related quality of life and productivity burden for non-professional caregivers of adults with rare diseases: a real-world study.
Journal article
Johnson B. et al, (2025), Orphanet j rare dis, 20
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An artificial intelligence algorithm to improve diagnosis of vertebral fractures embedded in fracture liaison services can reduce fractures and reduce costs
Conference paper
Pinedo Villanueva R. et al, (2025), 2025 wco abstract book
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Distinct clusters of carers with X-linked hypophosphataemia based on their quality of life
Conference paper
Njuki L. et al, (2025), 2025 wco abstract book
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The World Hip Trauma Evaluation (WHiTE) platform trial: a framework for randomized comparisons of interventions for fragility hip fracture.
Journal article
Costa ML. et al, (2025), Bone jt open, 6, 383 - 390