Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

On Wednesday 12th October over 70 scientists from academia, healthcare, and industry came together to discuss the use of challenge models in the development of therapeutics. The symposium was organised by NDORMS Clinical Therapeutics group (James Fullerton and Duncan Richards).

The programme covered a wide range of issues relating to the use of challenge agents in human clinical studies and was kindly sponsored by the British Journal of Clinical Pharmacology.

Human challenge studies have utility across a range of therapeutic areas but teams are often working in small groups. It was fantastic to witness the energy during the panel discussions and the connections made during the breaks as participants discussed solutions to shared problems.

Duncan Richards, Climax Professor of Clinical Therapeutics

 

Oxford has a long history of conducting innovative experimental medicine studies that deliver real-world impact. This symposium showed that the future will be bright as well, highlighting our growing expertise in the field, the potential of technical advances to deliver new biological insight and the value of both cross-disciplinary and academic-industry collaboration.”

                        James Fullerton, Associate Professor of Clinical Therapeutics

Audience at the challenge trial symposium

The World Health Organization (WHO) describes human challenge studies as Trials in which participants are intentionally challenged (whether or not they have been vaccinated) with an infectious disease organism.”

Researchers are then able to monitor the response to that challenge agent and make informed decisions about whether medicines should be further tested in larger scale clinical studies to treat disease.

Similar stories

An ambulance to Ukraine

Prof Lavy and OUH Consultant Anaesthetist Dr Viv Addy take ambulance of supplies to Ukraine border.

The Open Arms away (not away) day!

Despite not being able to meet in person, the Open Arms PPI group held a virtual away day, sharing ideas for its future development.

Resilience, adaptability, collaboration, creativity, self-care, and family.

International Women’s Day Event: ‘Women and the Pandemic’

NDORMS Writing Club

Louise Hailey shares her experience of the NDORMS Writing Club.

Meat the future - The Oxford Natural History Museum

Earlier this year, the histology team at The Kennedy Institute were thrilled to receive an enquiry like no other. We are used to processing and sectioning a wide variety of tissues for Oxford university researchers as well as other British and European institutions; however, we never expected to deal with chicken breast and beef steak from Sainsburys!