Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The CEDAR trial has been given the green light and is now open to recruitment.

CEDAR logo

The CEDAR trial has now received OCTRU Green Light approval to commence recruitment, with the Churchill Hospital, Oxford, planning to be the first site to be activated in early July 2019.

CEDAR is a phase 1 trial investigating the safety, tolerability and biological effects of intravenous enadenotucirev, a novel oncolytic virus, in combination with standard of care chemoradiotherapy.

Up to 30 Patients with locally advanced rectal cancer will be recruited from 4 sites across the UK and will be allocated to one of 6 different dosing schedules, consisting of 2 different doses of the virus given over 3 different frequencies. A time to event continual reassessment method, alongside input from the TMG, will be used to decide the dosing schedule that is assigned to each patient. The primary objective of the trial is to determine the optimal dosing schedule that can be administered with chemoradiotherapy.

CEDAR is sponsored by the University of Oxford, funded by CRUK and PsiOxus Therapeutics, and managed by the Oncology Clinical Trials Office (OCTO). Statistical support is provided by the Centre for Statistics in Medicine (CSM). The Chief Investigator is Professor Maria Hawkins.

 

Similar stories

Celebrating Clinical Trials Day at NDORMS

To mark Clinical Trials Day we take a look at some of the recent developments at NDORMS and celebrate the teams that make this important area of our research programme possible.

Breakthrough in treatment for Dupuytren’s disease

Injection of the anti-TNF drug adalimumab into Dupuytren’s disease nodules is effective in reducing nodule hardness and nodule size.

Liposomal bupivacaine found to be no more effective than current treatments for post-operative knee pain

A new study published in JAMA, has found that a drug recently licensed in the UK has no effect on post-operative knee replacement recovery or pain, compared to the current treatment when administered at site of surgery.

Cemented hip replacement improves quality of life for patients over 60

The White 5 trial compared implants fixed with bone cement against uncemented implants for hip fractures treated with hemiarthroplasty.

FUTURE-GB looking ahead to 2022

FUTURE-GB has bounced into 2022 ahead of both predicted recruitment into Stage 2 (the Randomised Controlled Trial), and the sites open in Stage 2! Congratulations to all our sites for their hard work so far.