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MACRO logo

We are delighted to announce that the MACRO Trial is now open to recruitment! MACRO: Defining best Management in Adult Chronic RhinOsinusitis is a multicentre RCT which aims to establish the comparative effectiveness of a prolonged course of antibiotics (clarithromycin) or endoscopic sinus surgery (ESS) in adult patients with CRS in terms of symptomatic improvement and costs to the NHS and patients, compared with standard medical care (intranasal medication) and each other at six months. The trial will begin recruitment at 6 pilot sites in the UK. For further information, please visit https://www.themacroprogramme.org.uk/ 

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