Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Researchers at NDORMS have developed a new set of guidelines for reporting mediation analyses in health research.

A new guideline has been developed to help scientists publish their research accurately and transparently. Published in JAMA, the AGReMA Statement (A Guideline for Reporting Mediation Analyses) provides recommendations for researchers who want to describe mediation analysis in their paper. Mediation analysis is primarily used to understand how an intervention works or why it does not.  

The checklists can be found on the AGReMA website, and the explanation and elaboration paper in JAMA explains the importance of each item and how the checklist can be used by authors, peer reviewers and journal editors. 

Hopin Lee, NHMRC Postdoctoral Research Fellow at NDORMS and lead author explained: “The use of mediation analysis has grown rapidly over the past 10 years across a wide range of disciplinesOur research has shown that their reporting has been poor and inconsistent, which makes it difficult to understand how the research was conducted and how reliable the findings are. We hope that the AGReMA statement will fix some of these issues. 

Gary Collins, director of the UK EQUATOR centre noted: “AGReMA was developed through a rigorous evidence- and consensus-based process using the EQUATOR methodological framework. We think it will be a useful tool for many researchers conducting mediation analyses of trials and observational studies.”   

Developed by an international team of methodologists, statisticians, clinical trialists, epidemiologists, psychologists, applied clinical researchers, clinicians, implementation scientists, evidence synthesis experts, representatives from the EQUATOR Network, and journal editorsthe consensus-based checklist provides detailed steps to help researchers present clear and transparent reports that will raise the standard of reporting of mediation analyses.  

AGReMA is not tied to a particular disease condition or subspecialty of medicine,” said Hopin. “Our working group will liaise with journal editors and funding agencies to increase awareness and encourage its use. Our hope is that it will be endorsed by journal editors, peer reviewers, and authors and improve the accuracy, completeness and consistency in reporting mediation analyses.”  

The development of AGReMA was supported by the Berkeley Initiative for Transparency in the Social Sciences, the Center for Effective Global Action, and the Laura and John Arnold Foundation. 

Similar stories

Adalimumab is found to be a cost-effective treatment for early-stage Dupuytren’s disease

Researchers at the Kennedy Institute of Rheumatology and Oxford Population Health’s Health Economics Research Centre have found that anti-TNF treatment (adalimumab) is likely to be a cost-effective treatment for people affected by early-stage Dupuytren’s disease.

Patients like me

What can patients learn from the experiences of people like them who’ve already had a hip replacement? A new tool called ‘Patients like me’ helps answer some of the questions about pain, complications and how long the prosthesis might last.

Study reveals new evidence on rare blood-clotting condition after covid-19 vaccination

Researchers from NDORMS at the University of Oxford have investigated claims that some adenovirus-based COVID-19 vaccines increase the risk of rare blood clots compared to their mRNA-based counterparts.

NDORMS contributes to new UK research to tackle monkeypox outbreak

The UK’s efforts to tackle the monkeypox outbreak will receive a huge boost with the creation of a new research consortium and a new study to study vaccine effectiveness.

World Osteoporosis Day 2022

A bone-healthy lifestyle is vital for strong bones and a mobile, fracture-free future. On World Osteoporosis Day, we are sharing advice from the International Osteoporosis Foundation (IOF), on putting your bone health first.

Mathematician boosts data science research at the Kennedy Institute

Welcome to Yang Luo who has joined the Kennedy Institute as the Principal Investigator of the Luo Group. Her lab is leading the investigation into how genetic variations contribute to diseases of the immune system.