Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

NIHR Health Technology Aassessment is funding a new study looking at the risks and benefits of first line osteoporosis medications (oral bisphosphonates) amongst patients suffering from chronic kidney disease, led by Associate Professor Daniel Prieto-Alhambra of NDORMS.

Around 3 million people suffer from osteoporosis in the UK and about 27% of those have at least moderate chronic kidney disease (CKD).

Osteoporosis weakens bones and makes them fragile and more likely to break. Currently, first line therapies for the prevention of the condition include oral bisphosphonates, a type of drug known to reduce the risk of fracture and improve bone density within 6 months of therapy. However, little is known about the impact of this type of drug on chronic kidney disease.

The new study, to start in December this year, will provide key information on the association between oral bisphosphonates and both the rates of fractures (benefit) and potential side effects amongst patients with different stages of CKD. This will benefit not only patients and but also the NHS: clarifying whether the use of this type of drug is safe and effective in patients with CKD will enable an informed decision on whether UK patients with CKD should be treated with these drugs.

Associate Professor Daniel Prieto-Alhambra says: "Patients with renal impairment have an increased risk of fractures. However, the most commonly used drugs to prevent these could have serious side effects for them. We will use data from thousands of patients with CKD who have been previously exposed to bisphosphonates to determine whether these medications are both safe and effective for them."

The study will use 'real life' data as routinely collected in NHS clinical practice, including primary and hospital care anonymised records for millions of UK people, ensuring the study fully represents the general population of patients. This will make our findings a key piece of information for clinicians treating and patients suffering from kidney impairment considering bisphosphonate therapy across the NHS.

You can read more about this study here.

 

This project is funded by the National Institute for Health Research Health Technology Assessment, with project number 14/36/02: Risks and benefits of bisphosphonate use in patients with chronic kidney disease: a population-based cohort study.

Similar stories

Cognitive–behavioural therapy consistently improves quality of life

Main Rehabilitation and self-management Research

A meta-review of the available research into cognitive behavioural therapy reveals it consistently improves health-related quality of life across different medical conditions and demographic populations.

Oxford to collaborate with Janssen to map the cellular landscape of immune mediated disorders

Main Research

The University of Oxford has entered into a strategic collaboration with Janssen Biotech, Inc., one of the Janssen Pharmaceutical Companies of Johnson & Johnson.

Versus Arthritis Foundation Fellowship awarded to Dr Kristina Zec

Awards Main

Dr Kristina Zec has been awarded a Versus Arthritis Foundation Fellowship to investigate the role of products of lipid oxidation produced by synovial macrophages in triggering articular inflammation.

Study reveals the safety of bisphosphonates in chronic kidney disease

Main

The results of an observational study published in JMBR and funded by the Health Technology Assessment Programme shows that bisphosphonate use is associated with a greater risk of chronic kidney disease progression.

WHiTE Four trial results published

Hip Main OCTRU Orthopaedics and trauma Research

The results of the WHiTE Four clinical trial for the treatment of fragility hip fractures have been published in The Bone and Joint Journal.

Vascular loss shown to be the primary hallmark of aging

Kennedy Main Tissue remodelling and regeneration

New Research from the Kusumbe group at the Kennedy Institute of Rheumatology identifies vascular attrition, marked by pericyte to fibroblast differentiation, as a primary hallmark of aging and highlights organ-specific vascular changes with age.