Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Overhead view of colourful numbers on white background.

 

Professor John Matthews gave an interesting talk about the bias introduced to binary outcomes in randomised controlled trials due to omitted covariates (both known and unknown). The rest of the meeting was taken up with updates and discussion. The Development of Statistical Analysis Plans has been funded by a Methodological grant and will be taken forward over the next few months with the aim of providing guidelines for SAPs, similar to the SPIRIT guidelines for protocols. A project on Trial Steering Committees has also been funded and an update on the Review of current practices and Opinions of Trial Steering Committees and a Review of a cohort of published literature for reporting of the remits and Functions of TSCs was provided. The aim of this project is to provide guidelines and a charter as per the Damocles Charter for Data Monitoring Committees. A discussion around providing a database of expert statisticians who will be able to be approached to be independent statisticians on either a DMC or a TSC was also discussed with particular emphasis on the definition of expert and what searchable features would be required. We also discussed how to enable the development of new statisticians to become experts in order to widen the existing limited pool of experienced experts. 

Similar stories

Adalimumab is found to be a cost-effective treatment for early-stage Dupuytren’s disease

Researchers at the Kennedy Institute of Rheumatology and Oxford Population Health’s Health Economics Research Centre have found that anti-TNF treatment (adalimumab) is likely to be a cost-effective treatment for people affected by early-stage Dupuytren’s disease.

Three NIHR HTA grants awarded to Professor Tim Theologis

Congratulations to Professor Tim Theologis, who has been awarded three NIHR HTA grants to extend research in orthopaedic disorders in children.

Going straight to surgery found to be better than undergoing rehabilitation first for longstanding anterior cruciate ligament injury

New research, funded by the National Institute for Health and Care Research (NIHR), shows initial surgery to be more successful and cost effective than undergoing treatment with rehabilitation first to treat longstanding anterior cruciate ligament injury.

Oxford receives NIHR funding to test anti-TNF on post operative delirium

Researchers at the University of Oxford have been awarded a grant from the National Institute for Health and Care Research (NIHR) to investigate whether anti-tumour necrosis factor (TNF) therapy can reduce or prevent post operative delirium/cognitive deficit.