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WHIST logo

A Randomised Controlled Trial of standard wound management versus negative pressure wound therapy in the treatment of adult patients having surgical incisions for major trauma to the lower limb

WHIST has now opened for recruitment in its first four pilot sites at Coventry, Nottingham, South Tees and Oxford. Sites at Bristol and Northumbria will follow shortly afterwards. The Pilot phase will confirm the expected rate of recruitment in this large-scale multi-centre randomised control trial.

We are currently contacting potential Main Phase sites at Major Trauma Centres across the UK to begin a gradual role out in October 2016.

Participants who are aged 16 years and older, who have sustained a lower limb fracture due to major trauma which requires a surgical incision, may be eligible to enter the trial.

The primary outcome measure is the rate of ‘deep infection,’ as per Centres for Disease Control and Prevention criteria, at 30 days

The secondary outcome measures include:

  • Disability Rating Index and general Health-related Quality of Life at 3 & 6 months and 5 years
  • Quality of wound healing
  • Further interventions related to the injury
  • Cost-effectiveness of Negative Pressure Wound Therapy versus standard dressing for wounds associated with major trauma to the lower limbs

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