Oxford BRC Stats Hub Lunchtime Seminar Series: Multilevel modelling in clinical trials
Daphne Kounali
Wednesday, 09 April 2025, 1pm to 1.30pm
Hosted by octru-stats@ndorms.ox.ac.uk
This is the eighth (and final) in a series of lunchtime seminars organised by the Oxford BRC Statistics Hub. Each seminar is 20 minutes long followed by 10 minutes of Q&A, and will be held via Microsoft Teams. These seminars are open to all in the University of Oxford and Oxford University Hospitals NHS Trust.
Multilevel modelling in clinical trials
Daphne Kounali - OCTRU Lead Statistician
A multilevel model is a statistical tool used to analyze data with a complex dependence structure, such as when patients are nested within hospitals or when there are multiple levels of treatment providers and geographic locations. In this seminar, I will define the different types of structures in clinical trials and discuss various applications of multilevel models, including incorporating repeated measurements, accounting for drop-out, and addressing measurement error. I will demonstrate how realistic assumptions and focusing on structure can help understand contextual effects and heterogeneity in outcomes, providing more precise estimates of treatment effects and predictions.
No registration is required.
Click here to join the session.
External Training
These links lead to a variety of clinical research related resources, training opportunities and conferences offered by external organisations – OCTRU does not necessarily endorse the links – this is offered only as a resource for individuals to use when looking for wider opportunities.
Note: We endeavour to keep this page up to date, however if a link is broken please can you let the admin team know on octrutrialshub@ndorms.ox.ac.uk
Training Opportunities
Training provided in Clinical Trials by the University of Oxford
Training in Research Integrity & Ethics
Research Governance, Ethics & Assurance Team (RGEA)
UKCRC Registered Clinical Trial Units
Monitoring of clinical trials - Online Training Modules
Resources about Human Tissue Act
Resources about Public Engagement
Health Research Authority (HRA)
National Institute of Health Research (NIHR) including NIHR Learn
Integrated Research Application System (IRAS)
NIHR Research & Design Services (RDS South Central)
This team have regular emails with links to training opportunities offered by themselves and other – follow this LINK to register for these alerts.
NIHR Learning for Involvement - training and resources dedicated to learning and development for public involvement in health and social care research
NIHR Associate Principal Investigator Scheme Resources Site
E-Learning
Training offered on Good Research Practice, including GDPR, Human Tissue legislation, IRAS - follow this LINK
National Institute of Health Research (NIHR Learn)
Online training courses for those working on trials, including those with an ac.uk email address. Courses include Introduction to GCP and refresher GCP training, diversity and inclusion training, and more - follow this LINK
LinkedIn Learning
Conferences
Biannual conference for researchers and practitioners to present the very latest in trials methodology research
Society for Clinical Trials (US organisation)
Annual conference in the US for those working in trials