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As part of OCTRU’s goal to ensure that clinical trials are designed and executed to the highest methodological and ethical standards, we participate in, and lead, methodological research of relevance to clinical trials. This also ensures that OCTRU gains and retains a position of leadership in the field, and is recognised internationally as a focus for high quality clinical trial design, conduct and reporting.

Trials in Follow up

 

International Initiatives

Individuals within the OCTRU team play a lead role in a number of international initiatives aimed at improving the design, conduct and reporting of clinical trials, including:

Initiative Description
CONSORT Consolidated Standards of Reporting Trials: an international initiative to alleviate the problems arising from inadequate reporting of randomised controlled trials. An update of CONSORT 2010 and to combine with SPIRIT is currently in progress.
SPIRIT Standard Protocol Items: Recommendations for Interventional Trials: an international initiative that aims to improve the quality of clinical trial protocols by defining an evidence-based set of items to address in a protocol. An update of SPIRIT and to combine with CONSORT 2010 is currently in progress.
DELTA2 Guidance on reporting target difference and sample size calculations for randomised controlled trials.
EQUATOR Enhancing the QUAlity and Transparency Of health Research Network: an international initiative that seeks to improve the reliability and value of published health research literature by promoting transparent and accurate reporting and wider use of robust reporting guidelines.
COCHRANE ROB-2 Risk of Bias-2 tool: an international initiative to develop a tool to assess the risk of bias in randomised trials included in systematic reviews.

 

National and Local Initiatives

Individuals within the OCTRU team also play a lead role in a number of national and local initiatives aimed at improving the design, conduct and reporting of clinical trials, including:

Initiative Description
MRC Trial Methodology Research Partnership A network of UK, institutions and partners working in trials and trials methodology research aimed at advancing trial methodology, developing capacity and further reducing research waste.
UKCRC Registered Trials Network Developing Statistics specific GCP training.
NIHR HTA Clinical Evaluation and Trials Record NIHR funding committee for clinical evaluation and trials.

 

Students and Fellowship

We are involved in supervising post-doctoral, doctorial and pre-doctorial researchers within NDORMS and the University of Oxford more broadly, conducting methodological research of relevance to clinical trials.

Project Funder Student
Improving the reporting in randomised clinical trials through observational and interventional research: From study protocols and registries to full text publications Swiss National Science Foundation Beni Speich (Post-doctoral Fellowship, University of Oxford)
Investigating the use of pre-specified criteria to inform progression from a randomised pilot study to a definitive randomised controlled trial Oxford MRC-DTP Studentship Katie Mellor (Doctorial, University of Oxford)
Addressing challenges in the design, analysis and reporting of factorial randomised controlled trials NIHR pre-doctorial fellowship Ioana Marian (Pre-doctorial, University of Oxford)
Developing a core outcome sets for lower limb orthopaedic surgery for ambulant children with Cerebral Palsy

Hajar Almoajil (Doctorial, University of Oxford)

Assessing the generalisability of trial findings using large orthopaedic population studies NIHR pre-doctorial fellowship

Dongquan Bi (Pre-doctorial, University of Oxford)

Development of a Novel Outcome Measure for Forensic Psychiatric Services NIHR doctorial felllowship Howard Ryland (Doctorial, University of Oxford)

Understanding and Preventing Surgical Site Infection following Surgery for Hand and Wrist Trauma

Justin Wormald (Doctorial)

 

Recent and Current Methodology Projects

We also conduct methodological research aimed at improving the design, conduct and reporting of clinical trials.

Please visit this link to see our publication list!