Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Wear particles, found at the bone-implant interface surrounding a loose prosthesis, are commonly phagocytosed by macrophages. Wear particles and wear particle-containing macrophages are also found in regional lymph nodes draining arthroplasty tissues. The means by which wear particles are transported from arthroplasty tissues to lymph nodes is uncertain, as the presence or absence of lymphatic vessels in periprosthetic tissues has not been established.We determined immunophenotypic expression of LYVE-1 and podoplanin, two highly specific lymphatic endothelial cell markers, in the hip arthroplasty pseudocapsule surrounding the false joint and the bone-implant interface of the femoral and acetabular pseu-domembrane.LYVE-1+/podoplanin+ lymphatic vessels were not identified in the pseudomembrane but were found in the pseudocapsule. Normal bone did not contain lymphatic vessels.Our findings suggest that the wear particles shed at the bone-implant interface are not transported to draining lymph nodes by lymphatics directly from the pseudomembrane, but via the pseudocapsule. The absence of a lymphatic clearance mechanism may contribute to accumulation of wear particles at the bone-implant interface and promote periprosthetic osteolysis through stimulation of osteoclast formation and activity.

Original publication

DOI

10.1080/17453670710015175

Type

Journal article

Journal

Acta orthopaedica

Publication Date

04/2008

Volume

79

Pages

289 - 294

Addresses

Department of Pathology, Nuffield Orthopaedic Centre, Nuffield Department of Orthopaedic Surgery, University of Oxford, Headington, Oxford, UK.

Keywords

Acetabulum, Endothelial Cells, Lymphatic Vessels, Humans, Osteolysis, Prosthesis Failure, Arthroplasty, Replacement, Hip, Immunohistochemistry, Hip Prosthesis, Particle Size, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male