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Radiopaque cement containing barium sulfate causes significantly more bone resorption in vivo and in vitro than radiolucent cement. The aim of this study was to investigate the osteolytic potential of an alternative radiopaque agent, triphenyl bismuth (TPB). Bone cement particles containing various concentration of TPB (15 and 25 wt %) prepared by two methods, blending and dissolution, were added to monocytes in a bone resorption assay and the extent of lacunar resorption on dentine slices was determined. The results clearly show that cement particles containing TPB cause less bone resorption than cement particles containing barium sulfate. In addition, our results suggest that TPB prepared by dissolution in bone cement induces less osteolytic response than TPB-cement prepared by blending. The osteolysis in response to bone cement wear particles may therefore be reduced with TPB prepared using the blending technique.

Original publication




Journal article


J biomed mater res b appl biomater

Publication Date





64 - 73


Animals, Bone Resorption, Cells, Cultured, Contrast Media, Materials Testing, Mice, Monocytes, Organometallic Compounds, Osteoclasts, Osteolysis, Polymethyl Methacrylate, Radiography, Terphenyl Compounds