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The serum concentrations of vitamin D metabolites and biochemical markers of bone metabolism were measured in 15 patients with established non-union of fracture and in 15 age- and sex-matched controls. No significant differences between the two groups were observed in the concentrations of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3; or in the biochemical indices of skeletal metabolism. These results suggest that patients with established non-union have normal bone turnover with no evidence of disturbed production or utilization of 24,25-dihydroxyvitamin D3 or other major vitamin D metabolites. Disturbances in vitamin D metabolism are unlikely therefore to make a major contribution to the maintenance of non-union of fracture.


Journal article


Bone miner

Publication Date





205 - 209


24,25-Dihydroxyvitamin D 3, Adolescent, Adult, Aged, Aged, 80 and over, Bone and Bones, Dihydroxycholecalciferols, Female, Fractures, Ununited, Humans, Male, Middle Aged, Vitamin D