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The Transforming Growth Factor-beta (TGF beta) family of polypeptides elicits diverse biological actions on a wide range of cell types. There are known to be several isoforms of TGF beta coded for by different genes, with possibly differential expression and potencies. We have demonstrated that there is constitutive expression of three forms of transforming growth factor beta in adult human articular chondrocytes. The presence of 10% fetal calf serum in the culture medium may influence expression. The addition of transforming growth factor beta or interleukin 1 beta to the culture medium does not appear to consistently influence the expression of TGF beta by the cells.

Original publication

DOI

10.1016/s0006-291x(05)81108-8

Type

Journal article

Journal

Biochem biophys res commun

Publication Date

31/10/1991

Volume

180

Pages

602 - 608

Keywords

Base Sequence, Cartilage, Articular, Humans, In Vitro Techniques, Interleukin-1, Molecular Sequence Data, Multigene Family, Oligodeoxyribonucleotides, Polymerase Chain Reaction, RNA, Messenger, Recombinant Proteins, Restriction Mapping, Transforming Growth Factor beta